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From: TSS ()
Subject: 2ND Dominique Dormont International Conference
Date: December 2, 2005 at 8:50 am PST

2ND Dominique Dormont International Conference
Terry S. Singeltary Sr.

Fri Dec 2, 2005 10:45

2ND Dominique Dormont International Conference

Welcome address

Dominique Dormont died in November 2003, but his achievements and spirit remain as an example of total devotion to research on the pathogenesis of infectious diseases.
In his memory, we are pleased to announce the second of a series of Dominique Dormont Conferences on “Host-Pathogen Interactions in Chronic Infections”.

The Dominique Dormont Conferences are international forums to promote exchanges between clinicians and basic scientists, including veteran and young investigators, involved in research on chronic infections. This year the overall theme of the Conference will be “Pathogenesis of prion and viral infections”. Researchers with common interests will meet for few days of synthesis and discussion about recent advances in their fields with a view to formulating new research directions and collaborations. Contacts with young scientists will be strongly encouraged. To facilitate these exchanges, attendance at each conference will be limited to 150 participants. Topics will first be reviewed by veteran scientists and then followed by presentations from young investigators. Poster sessions will also provide a forum for scientific exchanges between older and younger researchers. An International Scientific Program Committee will establish the final program, in which original unpublished work will be strongly encouraged.

Paul BROWN, Jacques GRASSI and Daniel BÉQUET Domique Dormont Conference Chair and Co-Chairs

Thursday, December 1, 2005
5:30 p.m
6:00 p.m Introductory lecture
Development and plasticity of the brain
Alain Prochiantz (F)
6:00 p.m
7:30 p.m Session 1 : Mechanisma of neuronal cell death
6:00 HIV-1 coreceptors CCR5 and CXCR4 paradoxically can mediate neuronal cell death and protection
Markus Kaul (USA)
6:30 Depleting neuronal PrPc prevents neurotoxicity in prion infection
Giovanna Mallucci (UK)
7:00 Involvement of the kynurenine pathway in neuroinflammation
Guillemin GJ, Cullen KM, Smythe GA, Brew BJ
7:15 BSE prions target brain serotonin neurons
Vidal C, Herzog C, Callebert J, Kellermann O, Launay JM, Laplanche JL, Miquel MC, Carimalo J, Lefebvre-Roque M, Dormont D, Lasmézas C

Friday, December 2, 2005
9:00 a.m
10:30 a.m Session 2 : Pathogen propagation in the organism
9:00 TSE infection in sheep
Nora Hunter (UK)
9:30 Direct and indirect mechanisms of pathogenesis in TSE diseases
Bruce Chesebro (USA)
10:00 Human Cytomegalovirus in neural precursor cells
Wolmer N, Odeberg J, Seiger Å, Söderberg-Nauclér C.
10:15 Prion in muscle from Scrapie and BSE contaminated small ruminants
Andréoletti O., Beringue V., Morel N., Lacroux C., Mathey J., Ledur A., Lugan S., Costes P., Corbière F., Grassi J., Lantier F., Laude H., Schelcher F.
10:30-11:15 a.m. Coffee break
11:15 a.m
12:45 p.m Session 3 : Pathogen-immune system interactions
11:15 Pathogenesis of Creutzfeldt-Jakob disease in non human primate
Corinne Lasmezas (F)
11:45 Inflammation in murine prion disease
Hugh Perry (UK)
12:15 Collapsin-response mediator protein 2 -CRMP2 and T cell motility in HTLV-1- associated myelopathy
Vincent P, Vuaillat C, Marignier M, Wattel E, Pique C, Ozden S, Gessain A, Giraudon P
12:30 Rabies virus infection switches TLR-3-positive human neurons into strong producers of interferon-beta
Préhaud C., Mégret F., Lafage M., Lafon M
12:45- 2:30 p.m. Lunch and posters on site
2:30 p.m
4:00 p.m. Session 4 : Genetic susceptibility factors
2:30 The role of host PrP in TSE disease
Jean Manson (UK)
3:00 AIDS Restriction Genes : Discovery, mechanisms and clinical translation
Stephen O’Brien (USA)
3:30 The role of herpes simplex virus type 1 and of the type 4 allele of the apolipoprotein E gene in Alzheimer’s disease
Wozniak M, Itzhaki R, Shipley S, Dobson, C.
3:45 Variability of scrapie dissemination pathways between PRP genotype in sheep
Tabouret G., Clément G., Lacroux C., Morel N., Foucras G., Chabert A., Lugan S., Rouillon V., Eychenne F., Elsen J.M., Schelcher F., Andréoletti
4:00-4:45 p.m. Coffee break
4:30 p.m
6:00 p.m Session 5 : Cellular and non-cellular models of prion infection
4:30 Biological characteristics of different TSE agents in cell cultures
Laura Manuelidis (USA)
5:00 Neurotoxic cytosolic PrP and its implications in neurodegenerative disorders
Jiyan Ma
5:30 Gene targeted murine models to study the role of glycosylation in PrP biochemistry and TSE infection
Cancellotti E, Wiseman F, Tuzi NL, Baybutt H, Aitchison L, Monaghan P, Simpson J, Manson J
5:45 High levels of TSE infectivity can be associated with low levels of PrP-res
Barron RM, Campbell SL, King D, Chapman K, Manson JC

Saturday, December 3, 2005
9:00 a.m
11:00 a.m Session 6 : Therapeutic approaches targeting immune and central nervous systems
9:00 Therapeutic approaches of herpesviruses infections of the nervous system
Antonio VOLPI (Italy)
9:30 Byron Caughey (USA)
10:00 A bone-marrow derived macrophage nanoparticle delivery system for anti-retroviral medicines : Implications for treatment of HIV-1 infection and viral encephalitis
Gendelman Howard E.
10:15 Inflammatory response in human tick-borne encephalitis : analysis of postmortem brain tissue
Gelpi E, Preusser M, Laggner U, Garzuly F, Holzmann H, Heinz FX, Budka H
10:30 Anti-PrP immune effectors adoptively transferred into scrapie infected mice retain their functional properties and confer protection
Carnaud C, Gregoire S, Gourdain P, Levavasseur E, Bachy V, Bruley-Rosset M, Aucouturier P
10:45 MLV retroviruses enhance prion proteins releasing
Leblanc P, Alais S, Porto-Carreiro I, Lehmann S, Grassi J, Raposo G, Darlix J.L.
11:00-11:30 a.m. Coffee break
11:30 a.m
12:00 a.m Memorial lecture
Epidemiology of Transmission of Drug-Resistant Strains of HIV-1
Mark Wainberg (CND)
12:00 a.m
12:30 p.m Closing ceremony


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