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From: TSS ()
##################### Bovine Spongiform Encephalopathy ##################### Paris, November 26, 2005: BIO-MODELING SYSTEMS, the leading Predictive Integrative Biology company is invited to present, in Europe* on December 2nd 2005 and in the USA** on December 9th 2005, major achievements in the understanding of Prion (mad Cow) disease, end point of a joint scientific program implemented and carried out by BMSystems’ team of integrative biologists and the C.E.A. Neuroprion research team (coordinator of the European Centre of Excellence on neurodegenerative diseases) over a 12 months period. The depth of knowledge generated and the rapidity achieved through this joint effort in the understanding of a complex disease demonstrates the strong impact Predictive Integrative Biology coupled to Experimental Biology will have upon the management and success rate of the Pharma Industry’s R&D programs. A joint publication, scheduled for release beginning 2006, is underway. BIO-MODELING SYSTEMS http://www.bmsystems.net/ demonstrates for the 4th time in succession its ability to produce high precision predictive biological models directly leading to the discovery of new physiological pathways and new targets in the general context of highly complex human diseases such as neurodegenerative disorders (Creutzfeldt-Jakob [mad cow] Disease, Alzheimer disease, etc…) If available, we invite you to come to these presentations and have a talk with our CSO, Dr. François Iris, to discover and/or discuss the operational outputs of our Predictive Integrative Biology CADI™ methods and tools. In the meantime, we urge you to take a look at one of the model’s 8 predictions, validated in vivo, that was presented by the C.E.A. scientific team at the Prion 2005 Conference in Düsseldorf (October 19-21, 2005). The document is available on our website. The development of Creutzfeldt-Jakob Disease (CJD) implicates the prion protein together with three types of cells that constitute extensive populations undergoing complex interactions in the brain: the astrocytes, the microglial cells and the neurons. The molecular mechanisms of CJD pathogenesis remain unknown. Using its CADI technology, Bio-Modeling Systems has constructed a theoretical model of the disease. This model describes new pathways, together with their associated molecular targets, explaining in part the molecular mechanisms associated with CJD pathogenesis and disease progression. Three of these targets, hitherto never described in prion diseases nor in other neurodegenerative disorders, have been experimentally tested, both in vitro and in vivo, by the research team of Professor Deslys at the CEA (Fontenay-aux-Roses), coordinator of the European Centre of Excellence on neurodegenerative diseases. Two of the targets experimentally studied were shown to undergo substantial modifications, predicted by the model, both in cells infected in vitro and in mice infected in vivo. In accordance with the model’s prediction, these modifications first appear in the neurons and later in activated astrocytes. These results demonstrate for the very first time that a theoretical model can predict novel pathways and molecular targets specifically associated with the pathogenesis and the progression of prion diseases. *: The Franco-Quebecois Bio-Informatics International Conference, taking place within the European Biotech Crossroads meeting held in Lille and Paris, form November 28th 2005 to December 2nd 2005. **: The CHI’s international conference on “Analytical Methods for Metabolic Profiling: Solving Analysis Problems" in Orlando, Florida, on December 9th 2005. Do not hesitate to contact us for additional information Best regards Manuel GEA Co-founder & CEO BIO-MODELING SYSTEMS Predictive Integrative Biology 26 rue Saint Lambert 75015 PARIS FRANCE +33 6 83 06 12 72 email: manuel.gea@bmsystems.net http://www.bmsystems.net/ http://www.bmsystems.net/download/BMSYSTEMS-major-progress-in-prion-disease.pdf New insight in prion pathogenesis : from theoretical model of neuropathogenesis to experimental evaluations 1Lenuzza N., 1Charvériat M., 1Buon J.-G., 1Picoli C., 3Lampe P.-H., 3Santamaria P., 1Correia E., 1Freire S., 2Benhamida S., 3Iris F., 1Deslys J.-P., 1Mouthon F. 1CEA/DSV/DRM/GIDTIP, Fontenay-aux-Roses, France 2Pôle Santé-Biotechnologies Ecole Centrale Paris Châtenay-Malabry, France 3Bio-Modeling Systems, France Neuropathogenesis of prion diseases involve, on one hand, the prion protein itself and, on the other hand, neurons, astrocytes and microglial cells. Molecular mechanisms remain unknown. Integrative analysis based upon literature has allowed us to develop a theoretical model of prion neuropathogenesis. To evaluate the neuropathological mechanisms predicted by this theoretical model, we focused our experimental study on three original targets neither described in prion fields nor in neurodegenerative diseases. Overview of the computer-assisted model-building process The model result from the systematic destruction of ‘working hypothesis’ arising from the integration of published information into an indexed database. The hypotheses that could not be destroyed are merged into ‘meta-hypotheses’ that are in turn subjected to the destruction process. Theoretical description of the prion pathogenesis in the brain This model predicts a simultaneous implication three cells. In contact with neurons, PrPres would be deteriorated into small peptides, which would fix on calcium channels of the three cellular partners. It would disrupt the equilibrium between these cells, and lead to neurodegenerative lesions. Definition of the theoretical model of prion neuropathogenesis Results snip...full text ; TSS #################### https://lists.aegee.org/bse-l.html ####################
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