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From: TSS ()
Subject: FALL 2005 NATIONAL PRION RESEARCH PROGRAM INVESTIGATORS MEETING
Date: November 2, 2005 at 1:10 pm PST


8-9 December 2005
Westfield Marriott, Chantilly, Virginia

Welcome

Welcome to the Department of Defense (DoD) National Prion Research Program (NPRP) investigators meeting website.

The DoD NPRP was established in fiscal year (FY) 2002 by Congress with the priority goal of developing a diagnostic test to detect the presence of prion disease. The NPRP has also supported research into the means to prevent and manage transmissible spongiform encephalopathies (TSE). The NPRP investigators meeting will provide us with an opportunity to demonstrate the forward strides that the program has made toward achieving its goals and give you an opportunity to highlight your research results and interact with other funded NPRP investigators, program staff, and various Government representatives for DoD research priorities.

All NPRP principal investigators are required to present their research in poster format during the meeting, and many of the investigators will also be selected to present their research in platform presentations. Selections for the platform presentations will be based upon investigator-submitted abstracts and will be made by the meeting’s Technical Program Committee (TPC). We also encourage participation of co-investigators and trainees (post-doctoral and pre-doctoral candidates) that are supported by the program. Abstracts will be limited to a 300-word maximum and will be submitted through the Abstract Submissions page of this website. The cut-off date for abstract submissions is 31 July 2005.

The meeting is scheduled to be held 8-9 December 2005 at the Marriott Westfield’s Conference Center in Chantilly, Virginia.

If you have any questions regarding this website, please contact Helene Fredericks, CMP, at hfredericks@anteon.com or call 301-588-1700.


http://prion.anteon-conferences.com/index.htm



Vision
To eliminate the occurrence of human transmissible spongiform encephalopathies.

Mission
To develop a diagnostic test to detect the presence of prion disease.


Transmissible spongiform encephalopathies (TSEs) refer to several apparently related diseases including Creutzfeldt-Jacob disease (CJD) and its new variant (nvCJD), kuru, bovine spongiform encephalopathy ("mad cow disease"), and others. Except for nvCJD,TSEs appear to develop progressively over many years, lead to extensive central nervous system vacuole formation, and are invariably fatal. At present, definitive diagnosis can only be made at autopsy. The diseases are relatively rare in humans but have been documented most extensively in hoofed mammals. The current disease theory attributes TSEs to "prions," normal cell membrane proteins with atypical three-dimensional configurations, transmitted by ingestion or possibly blood transfer. Although a Nobel Prize was awarded for the work underlying this proposed mechanism (Prusiner, 1997), it remains controversial because disease transmission is traditionally associated with an agent capable of replication. The health threats posed by TSEs currently appear to involve the food and blood supplies. These health threats put military beneficiaries in affected areas overseas at risk. Research and development of means for diagnosis, prevention, and treatment face significant difficulties. These include uncertainty about disease mechanisms,TSEs’ slow progression in most cases, the lack of a diagnostic tool, and uncertainty about the similarities between animal and human diseases. In addition,TSE research requires BioSafety Level 3 facilities for some work.

Funding Opportunities
Search Awards
Integration Panels


Congressional Appropriations
$42.5 million in FY02
Research Program Fact Sheet


Funding Summary
38 awards in FY02


http://cdmrp.army.mil/nprp/default.htm


TSS



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