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From: TSS ()
Subject: SEAC 89TH MEETING ON THURSDAY 22ND SEPTEMBER 2005 AGENDA
Date: September 16, 2005 at 8:09 am PST

89th meeting on Thursday 22nd September 2005


http://www.seac.gov.uk/agenda/agen220905.htm

In BSE in cattle there is early infection of the ileum and tonsils, followed by later

infection of the CNS, dorsal root ganglia and trigeminal ganglia. Emerging Japanese

data suggests that there may be infectivity in peripheral nerves in clinical BSE.

http://www.seac.gov.uk/papers/tseroadmap05.pdf

TSE Roadmap – Scientific Opinions Final Version 6 September 2005

Page

1.1.7. SSC Opinion on Chronic Wasting Disease and Tissues that might carry a

risk for Human and Animal Feed Chains, 6-7 March 2003

Theoretical risk for prion transmission to humans consuming products of CWD

affected cervids of all ages cannot be excluded.

Similarly, transmission risk to domestic animals cannot be excluded4.

Early and widespread involvement of tissues in CWD-infected animals does not allow

definition of SRM list, nor to define age limits. Insufficient data to define exclusions or

amendment of any SRM rule on the basis of relative genetic resistance to infection.

Important to be certain that no risk of transmission of CWD from North America to EU

through trade in live cervids or their products.

No scientific data that CWD is present in countries outside North America (except

single import to Korea). However further European surveillance necessary.

1.1.8. SSC Opinion on BSE Risk of Autonomic Nervous System, 6-7 March 2003

Infectivity found in vagus nerve and sympathetic mesenteric ganglia of experimental

animals (mice/hamsters) and sheep infected with scrapie. Experimental data from

cattle insufficient, but infectivity in these tissues has not been shown in cattle5 other

than the inconsistent presence of disease-related PrP in the myenteric plexus

(network of nerve fibres throughout muscle of digestive tract) of cattle during the

Unclear whether scrapie models are applicable to pathogenesis of BSE. Cannot

exclude possibility that other autonomic NS structures carry infectivity in BSEinfected

Recommend collection of tissue samples appropriate to improving understanding role

of PNS and particularly the autonomic NS, from field cases and cattle in

4 See also 1.1.2. Experimental Transmission of Chronic Wasting Disease Agent from

Mule Deer to Cattle by Intracerebral Route, Hamir et al.2005, J Vet Diagn Invest

5 The Japanese Institute for Animal Health has detected Western Blot positives in

peripheral nerves in a fallen bovine. Further results are expected in late 2005/early

TSE Roadmap – Scientific Opinions Final Version 6 September 2005

Page 8 of 18

9 EC FAIR CT97 3308 Project

10 Refers to April 2004 SSC Opinion on oral exposure of humans to BSE agent:

infective dose and species barrier. This refers to small amount of tissue that can

contain an infective dose of BSE agent for cattle and sheep ( < 1 gram of

homogenised brain tissue). 2005 data suggests 1mg is sufficient to infect calves.

SNIP...

TSE Roadmap – Scientific Opinions Final Version 6 September 2005

Page 9 of 18

2.3.2. Unpublished Data from VLA, 2005

Unpublished data from a pressure rendering study indicates that BSE infectivity can

survive in tallow recovered by centrifugation and tallow recovered by solvent

extraction.

http://www.seac.gov.uk/papers/tseroadmap05-app3.pdf

Appendix 4 – A Summary of Opinions from the Spongiform

Encephalopathy Advisory Committee (SEAC)

http://www.seac.gov.uk/papers/tseroadmap05-app4.pdf

TSS




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