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From: TSS ()
Subject: Re: Abnormal PrP in the retina of the most commonly subtype sCJD
Date: August 22, 2005 at 6:59 am PST

In Reply to: Abnormal PrP in the retina of the most commonly subtype sCJD posted by TSS on August 20, 2005 at 6:48 am:


1: Rev Neurol (Paris). 2005 May;161(5):578-81.


[Heidenhain's variant of Creutzfeldt-Jakob's disease]

[Article in French]

Fauquembergue M, Tilikete C, Perret-Liaudet A, Kopp N, Krolak-Salmon P, Vighetto A.

Unite de Neuro-ophtalmologie et service de Neurologie D, Hospices Civils de Lyon, Hopital Neurologique Pierre-Wertheimer, Bron.

INTRODUCTION: Creutzfeldt-Jakob's disease has various anatomoclinical presentations including a rare form with preponderant visual signs described by Heidenhain. In this form, the visual symptoms may be isolated for a few weeks, leading to multiple ophthalmological examinations. OBSERVATION: We report the case of a 75-year-old woman who developed isolated visual disorders which rapidly increased over a period of two months. Addition of neurological symptoms, abnormalities of EEG and positivity of 14-3-3 protein led to the diagnosis of Creutzfeldt-Jakob's disease. The patient died 14 months after the first neuroophthalmologic signs. The diagnosis was established by post-mortem examination and immuno-electrophoretic demonstration of type 1 prion protein. CONCLUSION: Heidenhain's form of Creutzfeldt-Jakob's disease highlights the importance of general rules for prevention of iatrogenic hazard during ophthalmological examinations.

PMID: 16106810 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16106810&query_hl=10


TSS



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