I'm wondering if anyone can help me or has experienced the same thing? In the past 2 or 3 years (I'm 43), my tongue swells up really badly. It can be at 3 in the morning or 2 in the afternoon. In the beginning I was thinking it could have been fish or fruits even though I have eaten both all of my life. But I have not had either one of these today and here I am again with a swollen tongue. I am taking Zyrtek or Benadryl to help bring the swelling down. I have been tested for so many things and everything always comes back negative.