From a Dr. and Biochemist perspective, There are several forms of B-12
The traditional one, which is the cheapest for companies to acquire and sell is
cyanocobalamin, and it does has side effects.
It is contaminated with poisonous cyanide during its chemical extraction from animal tissues. Hence the name.
You want a methyl donor, thus ONLY buy B-12 in the form of Methylcobalamin
Methylcobalamin has "metabolic and therapeutic" applications according to Dr. Sahelian. He notes methylcobalamin helps in the formation of S-adenosylmethionine (SAM-e), a popular mood-altering compound. Chronic Fatigue Syndrome and Fibromyalgia patients have also reported an increase in health with the use of B-12.
of course pharmacies sell junk. LEF.org, mercola.com and vitacost.com is my preference for buying quality with value, the NSI brand. Why take Vitamin D2 and make your body convert it to D3, why take B12 as cyanocobalimin and make your body convert it it. Plus, you want a Methyl donor.
Just like you want sulfates.... Thus Glucosamine Hydroxide is junk, while Glucosamine Sulfate is what u want. MSM is Methylsulfonylmethane. Taken at 4,000 per day it is effective.
I notice NOTHING with garbage B-complex sold by the masses. When i take a B-complex from Vitacost.com 3 times a day, i don't need caffeine at all.
best of health.
Kidneys are NOT detected as impaired unless the nephrons are only working below 20% , less why in the world take your chances. Stop buying the Walmart and other store junk. You are not saving any money, spending more.... for garbage vitamins.
Plus, you need HCL to absorb your vitamins. If you on on a acid blocker, you are not going to absorb much. You really want to take apple cider vinegar with your vitamins.
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While we will agree that the methyl form is better, it can also be harder to find. Most pharmacies carry the cyano form since it is cheaper and more stable.
Thankfully, concern about cyanide from a cyanocobalamin supplement really only applies to people with compromised kidney function. See this website for more detail: http://www.veganhealth.org/b12/nocyano
Quote: "While being a natural chemical produced in the body, cyanide is toxic, and the body turns it into thiocyanate in order to excrete it. If this pathway is defective or overwhelmed through ingestion of too much cyanide (such as in smokers, or people in Nigeria who eat large amounts of cassava which is high in cyanide)... a different form of B12 should be given... "
So when the methyl form is available, great! However, for those of us who are non-smokers, rarely eat cassava, and have a healthy detoxification system, taking the cyano form is still a whole lot better than not taking any B12.
Jack Norris RD has responded directly to the comments made by Doug Graham, here:
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